General Anti-Cancer Therapies
- KDs target the Warburg effect, a biochemical phenomenon in which cancer cells predominantly utilize glycolysis instead of oxidative phosphorylation to produce ATP. Furthermore, some cancers lack the ability to metabolize ketone bodies, due to mitochondrial dysfunction and down-regulation of enzymes necessary for ketone utilization.
- We found that an ad libitum KD (8:1) with a fat content of 25% medium-chain triglycerides and 75% long-chain triglycerides produced a stronger anti-tumor effect compared to a KD (8:1) with all long-chain triglycerides
- "In total, we found 87 studies including 30 clinical studies and 57 original studies for rodents."
- "60% of the preclinical studies shown in Table 1 reported an antitumor effect of KDs, 17% did not detect an influence on tumor growth and 10% reported adverse or pro-proliferative effects"
- In most preclinical studies, KD slowed tumor growth, prolonged the survival rate, delayed the initiation of tumors, and reversed the process of cancer-induced cachexia
- In multiple studies, the KD sensitized cancer cells to classic chemo or radiotherapies.
- Furthermore, a study on different mouse cancer models, including pancreatic, bladder, endometrial, and breast cancer as well as acute myeloid leukemia, indicated that the KD enhances the efficacy of targeted therapy, in particular phosphatidylinositol-3 kinase (PI3K) inhibitors, and overcomes drug resistance, suggesting that the KD could be part of a multimodal treatment regimen to improve the efficacy of classic cancer therapy.
- Not all cancers respond positively to a ketogenic diet. In certain melanoma's it can promote tumor growth. 
- (BRAF V600E) that may cause tumors to preferentially metabolize acetoacetate is found in more than 60% of melanoma cancers, 100% of the hairy cell type of leukemia, 10% of colorectal cancers, and 5% of multiple myelomas in humans.
- In Squamous cell carcinoma (SCC), systemic glucose restriction by ketogenic diet and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate intratumoral oxidative stress and tumor growth inhibition.
- Elevated glucose influx fuels generation of NADPH and GSH, thereby heightening the anti-oxidative capacity in SCC tumors
- Reduction of blood glucose lowers blood insulin levels, which suppresses PI3K/AKT signaling in SCC cells.
- The combination of tomato and broccoli was more effective at slowing tumor growth than either tomato or broccoli alone
TUMOR REVERSION: CORRECTION OF MALIGNANT BEHAVIOR BY MICROENVIRONMENTAL CUES Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response
10) Erythropoietin Erythropoietin (EPO) is a hormone produced in the kidneys that controls red blood cell production (erythropoiesis) .
Natural ways to increase EPO in the body: Echinacea  Astragalus  Beetroot juice [10, 11] Spirulina  Dietary protein  Arachidonic acid  Cobalt  Portulaca oleracea L.  Rhodiola (Salidroside)  Rehmannia (Catalpol)  Emodin  Altitude training  Sauna