Vitamin C
Uses
- taking 500mg of vitamin C twice daily can help those with type 2 diabetes by lowering elevated blood sugar levels across the day and minimizing spikes in blood sugar after meals. It also helped to lower blood pressure.[1]
Overdosing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096888/ https://www.renalandurologynews.com/nutrition/vitamin-c-supplementation-and-ckd/article/138500/
"Because vitamin C is excreted by the kidney, intake greater than 100-200 mg/day should be avoided in CKD to avoid oxalosis, which is the accumulation of the metabolic by-product of ascorbic acid. Many organs and tissues of the body can be affected by oxalate deposits, including the kidneys.
Cases of acute renal failure (ARF) have been documented. Recently, Nankivell and Murali reported oxalosis resulting in graft failure in a kidney transplant recipient who had been taking self-prescribed doses of vitamin C 2,000 mg daily as a dialysis patient for the three years prior to transplant (N Engl J Med. 2008;358:e4).
Similarly, a case report by McHugh and colleagues (Anaesth Intensive Care. 2008;36:585-588) describes mortality from vitamin C-induced ARF. Oxalosis was confirmed on autopsy in this patient, who, unbeknownst to physicians, had been ingesting “several grams per day” of vitamin C in the belief that it would be beneficial for his health."
Absorption
- Vitamin C competes with glucose to penetrate cell membranes [2]
