Difference between revisions of "Berberine"
From Biohacking Wiki
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|image = | |image = | ||
− | |content-1 = | + | |content-1 = Berberine is a plant alkaloid with anti-diabetic action. |
− | |list-1 = | + | |list-1 = Lower blood sugar |
− | |list-2 = | + | |list-2 = Treat gastrointestinal infections |
− | |list-3 = | + | |list-3 = Alleviate dyslipidemia and cardiovascular diseases |
− | |split-content-left = | + | |split-content-left = 500mg 3x daily |
− | |split-content-right = | + | |split-content-right = with meals |
|notes = additional information, e.g. best form | |notes = additional information, e.g. best form | ||
}} | }} | ||
=What It Is= | =What It Is= | ||
+ | Berberine (molecular formula C20H19NO5 and molecular weight of 353.36) is the main active component of an ancient Chinese herb ''Coptis chinensis French'', which has been used to treat diabetes for thousands of years. | ||
=How It Works= | =How It Works= | ||
− | * berberine and metformin promote glucose metabolism by stimulating glycolysis, which probably results from inhibition of mitochondrial respiratory chain complex I, independent of AMPK activation.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114874/?report=classic</ref> | + | * berberine and metformin promote glucose metabolism by stimulating glycolysis, which probably results from inhibition of mitochondrial respiratory chain complex I, independent of AMPK activation.<ref name="ampk-study">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114874/?report=classic</ref> |
=Uses= | =Uses= | ||
==General Purpose== | ==General Purpose== | ||
* Lowering blood sugar <ref name="Diabetes-Efficacy"></ref> | * Lowering blood sugar <ref name="Diabetes-Efficacy"></ref> | ||
+ | * treat gastrointestinal infections | ||
==Conditions It Treats== | ==Conditions It Treats== | ||
* Type 2 Diabetes <ref name="Diabetes-Efficacy">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/?report=classic</ref> | * Type 2 Diabetes <ref name="Diabetes-Efficacy">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/?report=classic</ref> | ||
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***postprandial blood glucose(PBG) from 19.8 ± 1.7 to 11.1 | ***postprandial blood glucose(PBG) from 19.8 ± 1.7 to 11.1 | ||
***plasma triglycerides from 1.13 ± 0.13 mmol/L to 0.89 ± 0.03 mmol/L | ***plasma triglycerides from 1.13 ± 0.13 mmol/L to 0.89 ± 0.03 mmol/L | ||
+ | * alleviate dyslipidemia and cardiovascular diseases <ref>https://www.ncbi.nlm.nih.gov/pubmed/19687008/</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/21160701/</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/22188769</ref> | ||
=Warnings= | =Warnings= | ||
=How To Take It= | =How To Take It= | ||
+ | * Rhizoma Coptidis is a popular traditional Chinese herb used for treatment of inflammation and diabetes, and contains 5.2%–7.7% of berberine <ref name="ampk-study"></ref> | ||
=Where To Get It= | =Where To Get It= | ||
=Anecdotes= | =Anecdotes= |
Latest revision as of 10:59, 9 January 2020
Contents
Berberine Cheat Sheet
Summary
Berberine is a plant alkaloid with anti-diabetic action.
Top 3 Uses
- Lower blood sugar
- Treat gastrointestinal infections
- Alleviate dyslipidemia and cardiovascular diseases
How To Take It
Dosage
500mg 3x daily
Timing
with meals
Important Notes
additional information, e.g. best form
What It Is
Berberine (molecular formula C20H19NO5 and molecular weight of 353.36) is the main active component of an ancient Chinese herb Coptis chinensis French, which has been used to treat diabetes for thousands of years.
How It Works
- berberine and metformin promote glucose metabolism by stimulating glycolysis, which probably results from inhibition of mitochondrial respiratory chain complex I, independent of AMPK activation.[1]
Uses
General Purpose
- Lowering blood sugar [2]
- treat gastrointestinal infections
Conditions It Treats
- Type 2 Diabetes [2]
- Hypoglycemic effect similar to that of metformin:
- hemoglobin A1c from 9.5% ± 0.5% to 7.5% ± 0.4%
- fasting blood glucose from 10.6 ± 0.9 mmol/L to 6.9 ± 0.5 mmol/L
- postprandial blood glucose(PBG) from 19.8 ± 1.7 to 11.1
- plasma triglycerides from 1.13 ± 0.13 mmol/L to 0.89 ± 0.03 mmol/L
- Hypoglycemic effect similar to that of metformin:
- alleviate dyslipidemia and cardiovascular diseases [3][4][5]
Warnings
How To Take It
- Rhizoma Coptidis is a popular traditional Chinese herb used for treatment of inflammation and diabetes, and contains 5.2%–7.7% of berberine [1]
Where To Get It
Anecdotes
References
- ↑ 1.0 1.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114874/?report=classic
- ↑ 2.0 2.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/?report=classic
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/19687008/
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/21160701/
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/22188769