Caffeine
Contents
Summary
supplement summary
Top 3 Uses
- use 1
- use 2
- use 3
How To Take It
Dosage
dosage - mg/day, etc.
Timing
morning, evening, with or without meals
Important Notes
additional information, e.g. best form
What It Is
How It Works
Uses
General Purpose
Conditions It Treats
Warnings
Caffeine and Fasting
It upregulates protein kinase A (pkA), a protein that is reduced by prolonged fasting [1]
Caffeine may have a negative impact on those with already-impacted blood sugar control [2]
May slightly increase IGF-1 [3]
"Caffeine impairs the expression of β-integrin receptors and IGF-1 receptors, which is directly relative to the applied dosage and the resulting proportional impairment of MAP kinases related to these receptors (ERK1/2). The impairment of the cellular signal generated by the above-mentioned receptors might be a mechanism of impairment of collagen biosynthesis caused by the presence of caffeine. This is the first report about caffeine-induced inhibition of collagen synthesis in human skin fibroblasts." [4]
- Increases insulin, reduce insulin sensitivity, and increase cortisol levels[5]
- Increases epinephrine, serum-free fatty acids, lactate, and norepinephrine and lead to insulin resistance[6]
How To Take It
Where To Get It
Anecdotes
References
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/
- ↑ https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/blood-sugar/faq-20057941
- ↑ https://www.researchgate.net/publication/266675013_Impact_of_Caffeine_on_Circulating_Growth_Hormone_and_Insulin_Like_Growth_Factor-1_Levels_during_Endurance_Exercise
- ↑ https://www.dovepress.com/influence-of-caffeine-and-hyaluronicnbspacid-on-collagen-biosynthesis--peer-reviewed-fulltext-article-DDDT
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/17998023
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/16886964
