Colloidal Silver

From Biohacking Wiki

What It Is

Colloidal silver is a liquid with nanometer-scale particles of silver suspended in it, most often used for its antimicrobial properties. [1]

How It Works - Give me the science!

"The mechanism of action of silver is linked with its interaction with thiol group compounds found in the respiratory enzymes of bacterial cells. Silver binds to the bacterial cell wall and cell membrane and inhibits the respiration process (Klasen, 2000). In case of E. coli, silver acts by inhibiting the uptake of phosphate and releasing phosphate, mannitol, succinate, proline and glutamine from E. coli cells."[5]

"The mechanism for the antimicrobial action of silver ions is not properly understood however, the effect of silver ions on bacteria can be observed by the structural and morphological changes. It is suggested that when DNA molecules are in relaxed state the replication of DNA can be effectively conducted. But when he DNA is in condensed form it loses its replication ability hence, when the silver ions penetrate inside the bacterial cell the DNA molecule turns into condensed form and loses its replication ability leading to cell death. Also, it has been reported that heavy metals react with proteins by getting attached with the thiol group and the proteins get inactivated (Liau et al., 1997; Feng et al., 2000)." [5]

"The silver nanoparticles show efficient antimicrobial property compared to other salts due to their extremely large surface area, which provides better contact with microorganisms. The nanoparticles get attached to the cell membrane and also penetrate inside the bacteria. The bacterial membrane contains sulfur-containing proteins and the silver nanoparticles interact with these proteins in the cell as well as with the phosphorus containing compounds like DNA. When silver nanoparticles enter the bacterial cell it forms a low molecular weight region in the center of the bacteria to which the bacteria conglomerates thus, protecting the DNA from the silver ions. The nanoparticles preferably attack the respiratory chain, cell division finally leading to cell death. The nanoparticles release silver ions in the bacterial cells, which enhance their bactericidal activity (Feng et al., 2000; Sondi and Salopek-Sondi, 2004; Morones et al., 2005; Song et al., 2006)"[5]


  • Enhances the effect of other antibiotics against Staphylococcus aureus and Escherichia coli [6]
  • Topical antibiotic for treating wounds [7][3]
    • Silver sulfadazine depicts better healing of burn wounds due to its slow and steady reaction with serum and other body fluids[5]
    • Nanocrystalline silver creams, gels and dressings (poly vinyl nano-fibres) can reduce risk of infections in chronic wounds [5]
  • In one study it was shown to be toxic to human breast cancer cells [8]
  • Antimicrobial surgical masks and implements [5]
  • Food preservation [5]
  • Water filtration [5]
  • Oral cavity of periodontal infections [9]

How To Take It

It is best used topically at the site of a wound or infection.

How Not To Take It

  • One study showed it to be ineffective at combating sinus infections when used as a nasal spray [10]
  • The research for its efficacy in oral supplementation is sparse.


"The results of the present study suggest that silver NPs which were prepared using glucose as the reducing agent had a better particle uniformity and as a result superior anti-bacterial action compared to the nanosilver particles synthesized by using ethylene glycol. Although silver ions such as AgNO3 have a somewhat better antimicrobial effect but they are unstable in the presence of light or other radiation." [11]

Where To Get It