Difference between revisions of "Luteolin"
From Biohacking Wiki
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|image = | |image = | ||
|content-1 = supplement summary | |content-1 = supplement summary | ||
− | |list-1 = | + | |list-1 = Block mast cell stimulation |
− | |list-2 = | + | |list-2 = Lower histamine production |
− | |list-3 = | + | |list-3 = Help nervous system inflammation |
− | |split-content-left = dosage - mg/day | + | |split-content-left = dosage - 100 mg/day |
− | |split-content-right = | + | |split-content-right = with or without food. |
− | |notes = | + | |notes = May synergize with PEA-m & quercetin |
}} | }} | ||
=What It Is= | =What It Is= | ||
+ | A flavenoid found in many plants that is able to block mast cell stimulation and T cell activation. | ||
=How It Works= | =How It Works= | ||
+ | * Inhibits basophil release of IL-4 and IL-13 synthesis, as well as CD40 ligand expression <ref>https://www.ncbi.nlm.nih.gov/pubmed/16343431</ref> and activation of AP-1. | ||
+ | * Inhibits the IgE-mediated release of histamine, leukotrienes, prostaglandin D2, and granulocyte–macrophage colony-stimulating factor from human cultured mast cells.<ref>https://www.ncbi.nlm.nih.gov/pubmed/17713031</ref> | ||
+ | * Inhibits IgE-mediated histamine IL-6 and TNF-α release from bone marrow-derived cultured murine mast cells (BMMCs) and rat peritoneal mast cells<ref>https://www.ncbi.nlm.nih.gov/pubmed/10705729</ref> | ||
+ | * Luteolin reduces CNS inflammation by preventing monocyte migration across the BBB<ref>https://www.ncbi.nlm.nih.gov/pubmed/15611292</ref> and, like quercetin (Aktas * Inhibits macrophage myelin phagocytosis, as well as proliferation and activation of autoimmune T cells <ref>https://www.ncbi.nlm.nih.gov/pubmed/15276069</ref>. | ||
=Uses= | =Uses= | ||
==General Purpose== | ==General Purpose== | ||
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=Where To Get It= | =Where To Get It= | ||
=Anecdotes= | =Anecdotes= | ||
+ | =Resources= | ||
=References= | =References= | ||
[[Category:Supplements]] | [[Category:Supplements]] | ||
[[Category:Consumables]] | [[Category:Consumables]] |
Revision as of 11:40, 3 January 2020
Contents
Luteolin Cheat Sheet
Summary
supplement summary
Top 3 Uses
- Block mast cell stimulation
- Lower histamine production
- Help nervous system inflammation
How To Take It
Dosage
dosage - 100 mg/day
Timing
with or without food.
Important Notes
May synergize with PEA-m & quercetin
What It Is
A flavenoid found in many plants that is able to block mast cell stimulation and T cell activation.
How It Works
- Inhibits basophil release of IL-4 and IL-13 synthesis, as well as CD40 ligand expression [1] and activation of AP-1.
- Inhibits the IgE-mediated release of histamine, leukotrienes, prostaglandin D2, and granulocyte–macrophage colony-stimulating factor from human cultured mast cells.[2]
- Inhibits IgE-mediated histamine IL-6 and TNF-α release from bone marrow-derived cultured murine mast cells (BMMCs) and rat peritoneal mast cells[3]
- Luteolin reduces CNS inflammation by preventing monocyte migration across the BBB[4] and, like quercetin (Aktas * Inhibits macrophage myelin phagocytosis, as well as proliferation and activation of autoimmune T cells [5].