Difference between revisions of "Methylene Blue"

From Biohacking Wiki
 
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|image =
 
|image =
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|content-1 = supplement summary
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|content-1 = Helps mitochondria to produce ATP without oxygen (upregulates anaerobic ATP production), which improves cellular metabolism.
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|list-1 =  use 1
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|list-1 =  Improved memory
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|list-2 =  use 2
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|list-2 =  Treating methemoglobinemia induced by metabolic poisons such as nitrates, cyanide and others
 
|list-3 =  use 3
 
|list-3 =  use 3
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|split-content-left = dosage - mg/day, etc.
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|split-content-left = 4mg/kg
 
|split-content-right = morning, evening, with or without meals
 
|split-content-right = morning, evening, with or without meals
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|notes = additional information, e.g. best form
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|notes = WARNINGs:
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*Do not take alongside SSRI's or if you have severe renal insufficiency <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087269/</ref>
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* Beware of sourcing. Industrial / chemical grade can have up to 10% contaminants <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265679/</ref>
 
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}}
  
 
=What It Is=
 
=What It Is=
 
=How It Works=
 
=How It Works=
 +
MB accelerates the normally slow NADP (nicotinamide adenine dinucleotide phosphate) methemoglobin reductase pathway<ref>https://www.ncbi.nlm.nih.gov/pubmed/17572332</ref>, the mechanism by which physiologically produced methemoglobin is reduced. However, MB can also cause methemoglobinemia when administered at a higher dose<ref>https://www.ncbi.nlm.nih.gov/pubmed/6492250</ref>, due to its strong oxidizing capacity which produces equilibrium between hemoglobin and methemoglobin. Thus, MB has hormetic effects on oxygen saturation of hemoglobin, based on its concentration. At low doses, MB converts methemoglobin to hemoglobin, while at higher doses, it has the opposite effect, converting hemoglobin to methemoglobin.<ref name="dosage-study"></ref>
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*It is a strong monoamine oxidase inhibitor (MAOI) ~ 100 times more potent than moclobemide <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2078225/</ref><ref>https://paperity.org/p/51358534/methylene-blue-is-a-potent-monoamine-oxidase-inhibitor</ref>
 
=Uses=
 
=Uses=
 
===Improving Memory===
 
===Improving Memory===
 
*A single dose increased MRI-based response in brain areas that control short-term memory and attention. 7% Increase in correct responses<ref>https://pubs.rsna.org/doi/10.1148/radiol.2016152893</ref>
 
*A single dose increased MRI-based response in brain areas that control short-term memory and attention. 7% Increase in correct responses<ref>https://pubs.rsna.org/doi/10.1148/radiol.2016152893</ref>
 +
===Treating Methemoglobinemia===
 +
 
==General Purpose==
 
==General Purpose==
 
==Conditions It Treats==
 
==Conditions It Treats==
 +
*Alzheimer's Disease - MB has been shown to attenuate the formations of amyloid plaques and neurofibrillary tangles, and to partially repair impairments in mitochondrial function and cellular metabolism. It also plays a role in improving neurotransmitter production.<ref>https://www.ncbi.nlm.nih.gov/pubmed/19433072/</ref>
 +
 
=Warnings=
 
=Warnings=
 
=How To Take It=
 
=How To Take It=
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*The dose for maximum cognitive enhancement seems to be ~4mg/kg.<ref name="dosage-study">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867617/</ref>
 
*The dose for maximum cognitive enhancement seems to be ~4mg/kg.<ref name="dosage-study">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867617/</ref>
 
* WARNING: MB seems to have a hormetic response. Taking more than 4mg/kg lowers the effect, and more than 10mg/kg has been shown to inhibit cognitive function.<ref name="dosage-study"></ref>
 
* WARNING: MB seems to have a hormetic response. Taking more than 4mg/kg lowers the effect, and more than 10mg/kg has been shown to inhibit cognitive function.<ref name="dosage-study"></ref>
 +
* DO NOT COMBINE WITH SSRI's <ref>https://www.ncbi.nlm.nih.gov/pubmed/16978328</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/15362595</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/16460699</ref>
 
=Where To Get It=
 
=Where To Get It=
 +
*[https://science.bio/product/methylene-blue-solution/ Science.bio] sells independently lab tested batches for a reasonable price.
 
=Anecdotes=
 
=Anecdotes=
 +
=Resources=
 +
https://paperity.org/p/51358534/methylene-blue-is-a-potent-monoamine-oxidase-inhibitor
 
=References=
 
=References=
  

Latest revision as of 13:48, 23 January 2020

Methylene Blue Cheat Sheet

Summary

Helps mitochondria to produce ATP without oxygen (upregulates anaerobic ATP production), which improves cellular metabolism.

Top 3 Uses

  • Improved memory
  • Treating methemoglobinemia induced by metabolic poisons such as nitrates, cyanide and others
  • use 3

How To Take It

Dosage

4mg/kg


Timing

morning, evening, with or without meals

Important Notes

WARNINGs:

  • Do not take alongside SSRI's or if you have severe renal insufficiency [1]
  • Beware of sourcing. Industrial / chemical grade can have up to 10% contaminants [2]

What It Is

How It Works

MB accelerates the normally slow NADP (nicotinamide adenine dinucleotide phosphate) methemoglobin reductase pathway[3], the mechanism by which physiologically produced methemoglobin is reduced. However, MB can also cause methemoglobinemia when administered at a higher dose[4], due to its strong oxidizing capacity which produces equilibrium between hemoglobin and methemoglobin. Thus, MB has hormetic effects on oxygen saturation of hemoglobin, based on its concentration. At low doses, MB converts methemoglobin to hemoglobin, while at higher doses, it has the opposite effect, converting hemoglobin to methemoglobin.[5]

  • It is a strong monoamine oxidase inhibitor (MAOI) ~ 100 times more potent than moclobemide [6][7]

Uses

Improving Memory

  • A single dose increased MRI-based response in brain areas that control short-term memory and attention. 7% Increase in correct responses[8]

Treating Methemoglobinemia

General Purpose

Conditions It Treats

  • Alzheimer's Disease - MB has been shown to attenuate the formations of amyloid plaques and neurofibrillary tangles, and to partially repair impairments in mitochondrial function and cellular metabolism. It also plays a role in improving neurotransmitter production.[9]

Warnings

How To Take It

Dosage

  • The dose for maximum cognitive enhancement seems to be ~4mg/kg.[5]
  • WARNING: MB seems to have a hormetic response. Taking more than 4mg/kg lowers the effect, and more than 10mg/kg has been shown to inhibit cognitive function.[5]
  • DO NOT COMBINE WITH SSRI's [10][11][12]

Where To Get It

  • Science.bio sells independently lab tested batches for a reasonable price.

Anecdotes

Resources

https://paperity.org/p/51358534/methylene-blue-is-a-potent-monoamine-oxidase-inhibitor

References

  1. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087269/
  2. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265679/
  3. ↑ https://www.ncbi.nlm.nih.gov/pubmed/17572332
  4. ↑ https://www.ncbi.nlm.nih.gov/pubmed/6492250
  5. ↑ 5.0 5.1 5.2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867617/
  6. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2078225/
  7. ↑ https://paperity.org/p/51358534/methylene-blue-is-a-potent-monoamine-oxidase-inhibitor
  8. ↑ https://pubs.rsna.org/doi/10.1148/radiol.2016152893
  9. ↑ https://www.ncbi.nlm.nih.gov/pubmed/19433072/
  10. ↑ https://www.ncbi.nlm.nih.gov/pubmed/16978328
  11. ↑ https://www.ncbi.nlm.nih.gov/pubmed/15362595
  12. ↑ https://www.ncbi.nlm.nih.gov/pubmed/16460699
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